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Interleukin-6 Covaries Inversely With Cognitive Performance Among Middle-Aged Community Volunteers

Anna L. Marsland, PhD, RN, Karen L. Petersen, MS, Rama Sathanoori, MS, Matthew F. Muldoon, MD, MPH, Serina A. Neumann, PhD, Christopher Ryan, PhD, Janine D. Flory, PhD and Stephen B. Manuck, PhD

From the Behavioral Immunology Laboratory (A.L.M., R.S.) and the Behavioral Physiology Laboratory (K.L.P., S.A.N., J.D.F., S.B.M.), Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania; the Center for Clinical Pharmacology (M.F.M.) and the Department of Psychiatry (C.R.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and the Department of Psychiatry (J.D.F.), Mount Sinai School of Medicine, New York, New York.


Figure 112
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  		Figure 1. Mean performance on the Trail Making and Stroop Color-Word Task (with standard error bars) among individuals in the interleukin-6 tertile groups. (Note: Higher scores reflect better performance on the Stroop task and worse performance on Trail Making.)

 

Figure 212
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  		Figure 2. Mean performance on a subset of the Wechsler Memory Scale–Third Edition scales assessing auditory and visual attention/working memory (with standard error bars) among individuals in the interleukin-6 tertile groups.

 




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