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Stimulated Production of Proinflammatory Cytokines Covaries Inversely With Heart Rate Variability

From the Behavioral Immunology Laboratory (A.L.M., A.A.P.), Department of Psychology, University of Pittsburgh; Department of Psychiatry (P.J.G., J.R.J.), University of Pittsburgh School of Medicine, Departments of Psychiatry and Behavioral Sciences and Psychology (S.A.N.), Eastern Virginia Medical School, Behavioral Physiology Laboratory (S.B.M.), Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania.

View larger version (18K): [in this window] [in a new window]   Figure 1. Scatterplot of the relationship between HF-HRV and stimulated production of IL-6 showing the mean linear regression line with 95% mean prediction interval (both variables log normalized). HF-HRV = high frequency-heart rate variability; IL = interleukin.

View larger version (18K): [in this window] [in a new window]   Figure 2. Scatterplot of the relationship between rMSSD and stimulated production of TNF- showing the mean linear regression line with 95% mean prediction interval (both variables log normalized). rMSSD = root mean square of successive differences; TNF = tumor necrosis factor.